Sclerosing cholangitis [top]

  • Obstructive jaundice
  • Elevated ALP
  • Fatigue, pruritus

Gallstones [top]

  • Colicky right upper quadrant abdominal pain / epigastric pain
  • Obstructive jaundice
  • Murphy's sign positive

Dubin-Johnson syndrome [top]

  • Intermittent obstructive jaundice
  • Right upper quadrant pain
  • Normal: ALP, LFT
  • Increased: Urine bilirubin

Carcinoma of head of pancreas [top]

  • Painless, progressive, severe obstructive jaundice
  • Palpable gall bladder
  • Weight loss

Alcoholic hepatitis / cirrhosis [top]

  • Hepatic jaundice or obstructive jaundice
  • History of excessive alcohol consumption

Drug-induced jaundice [top]

  • Hepatic jaundice or obstructive jaundice
  • Hepatic: paracetamol, halothane
  • Obstructive: oral contraceptive pill, antibiotics etc.

Pregnancy [top]

  • Morning sickness, vomiting
  • Amenorrhoea
  • Obstructive jaundice
  • Amenorrhoea
  • Female of child-bearing age
  • History of sexual intercourse

Primary biliary cirrhosis [top]

  • Obstructive jaundice usually in females
  • Severe, progressive pruritus
  • Non-tender hepatomegaly
  • Xanthelasma, tendon xanthomas
  • Positive: anti-mitochondrial antibody, Elevated serum IgM