Malabsorption [top]

  • Recurrent diarrhoea, weight loss
  • Light coloured, bulky foul-smelling stools that float in the pan
  • Causes include chronic pancreatitis, coeliac disease, Whipple's disease

Gastric carcinoma [top]

  • Epigastric pain
  • Persistent vomiting, haematemesis, melaena
  • Weight loss
  • Early saiety
  • Troisier's sign - palpable supraclavicular lymph node

Carcinoma of cardia of the stomach [top]

  • Progressive dysphagia to liquids then solids
  • Epigastric pain
  • Weight loss

Thyrotoxicosis [top]

  • Palpitations
  • Tachycardia
  • Anxiety
  • Weight loss
  • Diarrhoea

HIV [top]

  • Recurrent diarrhoea
  • Weight loss, Lymphadenopathy
  • Opportunistic infections: Candidiasis, PCP pneumonia, Crytococcal meningitis

Chron's disease [top]

  • Recurrent diarrhoea with rectal bleeding
  • Central abdominal pain
  • Right lower quadrant mass
  • Weight loss, Mouth ulcers, Fistulae
  • Large joint polyarthritis, sacroilitis

Colon cancer [top]

  • Abdominal pain
  • Weight loss
  • Recurrent diarrhoea alternating with constipation
  • Change in bowel habit, rectal bleeding
  • Tumour of descending colon can causeTenesmus

Renal carcinoma [top]

  • Painless haematuria
  • Triad of haematuria, loin pain and palpable mass
  • Fever, weight loss

Tuberculosis [top]

  • Weight loss
  • Cough
  • Haemoptysis
  • Fever
  • Malaise
  • Contact with TB
  • Opacity on CXR

Duodenal ulcer [top]

  • Burning epigastric pain
  • Relieved by food
  • Vomiting after eating, weight loss
  • Haematemesis or melaena if bleeding

Addison's disease [top]

  • Hyperpigmentation
  • Nausea / vomiting
  • Malaise, fatigue
  • Postural hypotension
  • Weight loss

Achalasia [top]

  • Frequent dysphagia
  • Intermittent vomiting
  • Regurgitation of undigested food
  • Weight loss

Hyperthyroidism [top]

  • Weight loss
  • Fine tremor, palpitations
  • Recurrent diarrhoea
  • Amenorrhoea
  • Increased sweating
  • Goitre

Malignancy [top]

  • Progressive over weeks / months
  • Associated symptoms of malignancy

Spinal tumour [top]

  • Progressive onset of constant back pain over months chronic back pain
  • Progressive neurological deficit affecting legs
  • May be weight loss associated with primary tumour

Rectal carcinoma [top]

  • Tenesmus, palpable mass on PR examination
  • Change in bowel habit, weight loss
  • Rectal bleeding

Lung abscess [top]

  • Haemoptysis
  • Fever
  • Weight loss
  • Productive cough with foul smelling sputum
  • Chest pain
  • Opacity with fluid level on CXR

Bronchial carcinoma [top]

  • Haemoptysis
  • Weight loss
  • Smoker
  • Clubbing
  • Pleuritic chest pain
  • Shortness of breath
  • Opacity on CXR

Oesophageal carcinoma [top]

  • Progressive dysphagia to liquids then solids which stick in throat
  • Epigastric pain
  • Weight loss
  • Vomiting, haematemesis, melaena

Small bowel tumour [top]

  • Vomiting after eating
  • Weight loss
  • Abdominal pain

Chronic infection [top]

  • Fever
  • Night sweats
  • Malaise
  • Weight loss

Oesophageal stricture [top]

  • Vomiting
  • Weight loss
  • Dysphagia
  • Dysphagia to solids
  • Previous f, radiation, ingestion of corrosive substances

Diabetes mellitus [top]

  • Polydypsia, Polyuria, Thirst
  • Weight loss
  • Fatigue

Carcinoma of head of pancreas [top]

  • Painless, progressive, severe obstructive jaundice
  • Palpable gall bladder
  • Weight loss

Depression [top]

  • Low mood, fatigue
  • Anhedonia, poor appetite
  • Early morning waking
  • Weight loss, change in bowel habit

Laryngeal carcinoma [top]

  • Progressive hoarseness over several months
  • Smoker
  • Dysphagia
  • Haemoptysis
  • Ear pain
  • Weight loss